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In recognition of International Overdose Awareness Day, the Charles Koch Foundation seeks to support research projects (e.g. papers, conferences, workshops, etc.) that explore innovative, community-based solutions that are targeted at destroying the root causes of substance abuse. To that end, we are actively soliciting proposals for projects to consider innovative solutions that seek to alleviate substance use disorders. We are especially interested in research that: - Addresses innovative ways to help individuals overcome substance use disorders, prevent drug overdoses, and increase the willingness of individuals to seek treatment for substance abuse. - Explores the root causes of addiction and substance use disorders as well as innovative means to prevent substance abuse by remedying these root causes. - Addresses the unintended consequences of current approaches to reduce drug overdoses and substance abuse. - Examines solutions that offer a proactive approach to fighting addiction rather than a reactive approach focusing on treatment and recovery. - Explores opportunities to reduce the stigma associated with substance use disorders and celebrate success in overcoming addiction and substance abuse.

Because the intent of the Innovator Award mechanism is to recognize these remarkably creative and innovative visionary individuals, rather than projects, the central feature of the award is the innovative contribution that the Principal Investigator (PI) can make toward ending breast cancer. The PI should have a record of challenging the status quo, shifting paradigms by changing a field of research or approach to patient care, exhibiting high levels of creativity, and demonstrating promise for continued innovation in future work. These rare individuals will be able to articulate a vision for ending breast cancer that challenges current dogma and demonstrates an ability to look beyond tradition and convention. The PI is also expected to be established in his/her field and have demonstrated success at forming and leading effective partnerships and collaborations. To further the development of innovative individuals and spark the generation of novel ideas, applications are required to incorporate the mentoring of promising junior investigators.

The Rita and Alex Hillman Foundation supports nurse-led healthcare innovation and research, with the goal of improving patient care in hospitals, clinics, homes, and communities. Nurses operate at the junction of public policy, medical science, systems-based healthcare delivery, and one-on-one patient care. Drawing on its knowledge of this unique and important role, the foundation believes it has valuable insights with respect to relevant modes of research and alternative models that can lead to more equitable, patient-centered health care. To that end, the foundation is accepting applications for its Hillman Emergent Innovation Serious Illness and End of Life Emergent Innovation program. Through the program, up to five grants of $50,000 will be awarded in support of pre-evidence or untested innovations that challenge traditional approaches to serious illness and end-of-life care and lead to bold, nursing-driven interventions targeting the unmet needs of vulnerable populations, including the economically disadvantaged, racial and ethnic minorities, LGBTQ people, the homeless, rural populations, and others.

The Child Health Foundation works to improve the lives of children in low-income settings by empowering local communities to creatively solve their most pressing child health challenges. To that end, the foundation is accepting applications for its Innovative Small Grants Program. Through the program, grants of up to $5,000 will be awarded in support of innovative research or innovative service projects aimed at improving the health and well-being of newborn infants during the first month of life. CHF will consider a range of technologies and approaches, including both biomedical and social projects that show promise, are innovative, and may have widespread application.

The Neuroendocrine Tumor Research Foundation-AACR Grant represents a joint effort to promote and support innovative cancer research. This grant is available to independent junior and senior investigators to develop and study new ideas and innovative approaches that have direct application and relevance to neuroendocrine tumors. Proposed research may be in any discipline of basic, translational, clinical, or epidemiological cancer research. Applications are invited from researchers currently in the field as well as investigators with experience in other areas of cancer or biomedical research who have promising ideas and approaches that can be applied to neuroendocrine tumor research.

The Neuroendocrine Tumor Research Foundation-AACR Grant represents a joint effort to promote and support innovative cancer research. This grant is available to independent junior and senior investigators to develop and study new ideas and innovative approaches that have direct application and relevance to neuroendocrine tumors. Proposed research may be in any discipline of basic, translational, clinical, or epidemiological cancer research. Applications are invited from researchers currently in the field as well as investigators with experience in other areas of cancer or biomedical research who have promising ideas and approaches that can be applied to neuroendocrine tumor research.

The NIDA Avant-Garde Award Program for HIV/AIDS Research supports individual scientists of exceptional creativity who propose high-impact research that will open new areas of HIV/AIDS research and/or lead to new avenues for prevention and treatment of HIV/AIDS among drug abusers.  The term "avant-garde" is used to describe highly innovative approaches that have the potential to be transformative.  The proposed research should reflect approaches and ideas that are substantially different from those already being pursued by the investigator or others.  The NIDA Avant-Garde award supports innovative, basic research that may lead to improved preventive interventions or therapies; creative, new strategies to prevent disease transmission; novel approaches to improve disease outcomes; and creative approaches to eradicating HIV or improving the lives of those living with HIV.

The NIDA Avant-Garde Award Program for HIV/AIDS Research supports individual scientists of exceptional creativity who propose high-impact research that will open new areas of HIV/AIDS research relevant to drug abuse and/or lead to new avenues for prevention and treatment of HIV/AIDS among drug abusers. The term "avant-garde" is used to describe highly innovative approaches that have the potential to be transformative. The proposed research should reflect approaches and ideas that are substantially different from those already being pursued by the investigator or others and should support the NIH HIV/AIDS Research Priorities https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-137.html. The NIDA Avant-Garde award supports innovative, basic research that may lead to improved preventive interventions or therapies; creative, new strategies to prevent disease transmission; novel approaches to improve disease outcomes; and creative approaches to eradicating HIV or improving the lives of those living with HIV.

The National Institute of Environmental Health Sciences (NIEHS) invites qualified investigators from domestic institutions of higher education to submit an application for Superfund Research Program (SRP) R01 Individual Research Project grant program. This Funding Opportunity Announcement (FOA) focuses on research that will advance effectiveness of bioremediation through incorporation of advanced, novel materials science approaches. Bioremediation refers to the use of biota (bacteria, algae, fungi, plants, etc.) to reduce or detoxify hazardous substances in the environment. Bioremediation is a cost-effective, low-energy-intensive remedy that has contributed to the cleanup and closure of sites impacted by hazardous substances. In recent decades, bioremediation has advanced from reliance upon culturing and biogeochemical processing to a technology-enabled field enhanced by high throughput molecular approaches (e.g. omics and gene editing techniques). These new approaches have elucidated molecular mechanisms responsible for contaminant cleanup and provided insight for potential solutions to naturally degrade emerging contaminants. Concurrent advances in materials science approaches present an opportunity to integrate new approaches to further refine the mechanisms of bioremediation and optimize conditions to accelerate natural degradation and/or stabilization processes. This Funding Opportunity Announcement calls for teams including bioremediation materials science (nanotechnology, microenvironmental engineering) to submit proposals to advance the knowledge and practice of bioremediation to address current and emerging recalcitrant hazardous substances and complex mixtures.

The primary objective of this FOA is to stimulate innovative Convergent Neuroscience (CN) approaches to establish causal and/or probabilistic linkages across contiguous levels of analysis (e.g., gene, molecule, cell, circuit, system, behavior) in an explanatory model of psychopathology. In particular, applicants should focus on how specific constituent biological processes at one level of analysis contribute to quantifiable properties at other levels, either directly or as emergent phenomena.  Although not required, it is preferable that applications link at least three levels of analysis and include an emphasis on genetics. The projects under this FOA will develop novel methods, theories, and approaches through a CN team framework, bringing together highly synergistic inter/transdisciplinary teams from neuroscience and "orthogonal" fields (e.g., data/computational science, physics, engineering, mathematics, and environmental sciences). Successful teams will combine, expand upon, or develop conceptual frameworks and theoretical approaches, and build explanatory computational models that connect contiguous levels of analysis. Such frameworks, theories, and computational explanatory models should be validated through experimental approaches to elucidate biological underpinnings of complex behavioral (including cognitive and affective) outcomes in psychopathology. Additionally, a goal of this program is to advance research in CN by creating a shared community framework of resources which may be used by the broader research community to further research, as such, successful team will have robust plan for sharing data and other resources.

The American Diabetes Association's Core Research Program funds research with novel and innovative hypotheses in any area relevant to the etiology or pathophysiology of diabetes.  To that end, the organization is accepting applications for its Innovative Basic Science (IBS) and Innovative Clinical or Translational Science (ICTS) Research Awards. Through the IBS program, grants of up to $115,000 a year for up to three years will be awarded in support of basic research with novel and innovative hypotheses in any area relevant to the etiology or pathophysiology of diabetes. Through the ICTS program, grants of up to $200,000 a year for up to three years will be awarded in support of research performed in human subjects, or research approaches designed to accelerate the transition of scientific discoveries into clinical application. Studies supported by these awards must directly involve human samples and/or data and should offer considerable potential for advancing the cure, prevention, and/or treatment of diabetes.

This announcement solicits applications for the Special Projects of National Significance Program (SPNS) initiative, Use of Social Media to Improve Engagement, Retention, and Health Outcomes along the HIV Care Continuum ¿ Demonstration Sites.  The purpose of this grant program is to support organizations that will implement, evaluate and disseminate findings from innovative methods for identifying, linking, retaining and improving health outcomes for HIV positive underserved, underinsured, hard-to-reach youth and young adults in HIV primary care and supportive services through the use of social media.  These methods are expected to include innovative system approaches using a variety of social media technologies or any other internet or mobile based applications, in the engagement and retention in care and viral load suppression of youth and young adults living with HIV.  The innovative system approaches proposed by the applicant organizations must be novel and will be tested and evaluated during the SPNS initiative, though certain components or tools of that system may have already been assessed through other studies.  Programs will be expected to implement and evaluate the effectiveness of their models¿ design including service utilization, treatment adherence, cost and impact on health-related outcomes, and to disseminate findings, best practices and lessons learned.  Successful applicants will be required to work collaboratively with a HRSA/HAB supported Evaluation and Technical Assistance Center (ETAC) throughout the four year project period.  This will include, but is not limited to, the collecting and reporting of data to the ETAC for a comprehensive multi-site evaluation, and the dissemination of successful models to the larger public health community.

This announcement solicits applications for the Rural Health Care Coordination Network Partnership Program (Care Coordination Program). The purpose of the Rural Health Care Coordination Network Partnership Program is to support the development of formal, mature rural health networks that focus on care coordination activities for the following chronic conditions: diabetes, congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD). Care coordination in the primary care practice involves deliberately organizing patient care activities and sharing information among all of the participants concerned with a patient¿s care to achieve safer and more effective care. Rural Americans are unhealthier, with higher rates of chronic illnesses, such as diabetes, CHF, and COPD and have higher rates of high-risk behaviors such as smoking, physical inactivity, and poor nutrition.[1],[2],[3],[4] These high-risk behaviors cause many of the illnesses, suffering and deaths due to chronic diseases and conditions.[5] The increasing prevalence of chronic diseases and the high cost of health care in the U.S. bring treatment of the ¿whole¿ person to the forefront, especially as there are often psychosocial (psychological and social) issues related to chronic diseases; for example, there is a link between diabetes and depression. In addition, more mental health problems are seen in the primary care setting than other health care settings; thus, integrating behavioral health care into primary care helps address both the physical and psychosocial aspects of health and wellness. Reviews and reports from the Agency for Healthcare Quality and Research (AHRQ) have shown a positive impact from integrating a team approach to care for a variety of disease conditions.[6] Health care coordination for people living with chronic conditions is vital to providing high quality care, especially in rural areas where access to health care is an issue. The main goal of care coordi

The purpose of this Funding Opportunity Announcement (FOA) is to promote innovative research on music and health with an emphasis on developing music interventions aimed at understanding their mechanisms of action and clinical applications with little or no preliminary data. Because of the need for a multidisciplinary approach, collaborations among basic researchers, translational science researchers, music intervention experts, other clinical researchers, music health professionals, and technology development researchers are encouraged. The FOA utilizes a phased R61/R33 funding mechanism to support mechanistic research and to evaluate the clinical relevance of music interventions. The R61 phase will provide funding to either investigate the biological mechanisms or behavioral processes underlying music interventions in relevant animal models, healthy human subjects, and/or clinical populations, or can be used to develop innovative technology or approaches to enhance music intervention research. The second R33 phase will provide support for further mechanistic investigations, intervention development, or pilot clinical studies. The pilot clinical studies may focus on intervention optimization/refinement, feasibility, adherence, and/or identification of appropriate outcome measures to inform future clinical research. Transition from the R61 to the R33 phase of the award will depend on successful completion of pre-specified milestones established in the R61.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) announces its interest in supporting meritorious research projects in three distinct domains related to cancer communication: 1) the utility and application of new cancer communication surveillance approaches; 2) the development and testing of rapid cancer communication interventions using innovative methods and designs; and 3) the development and testing of multilevel cancer communication models emphasizing bidirectional influence between levels. For such projects, applicants should apply communication science approaches to the investigation of behavioral targets and health outcomes related to cancer prevention and control. Applications should utilize one or more innovative communication research methodologies.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) announces its interest in supporting meritorious research projects in three distinct domains related to cancer communication: 1) the utility and application of new cancer communication surveillance approaches; 2) the development and testing of rapid cancer communication pilot interventions using innovative methods and designs; and 3) the development and testing of multilevel cancer communication models emphasizing bidirectional influence between levels. For such projects, applicants should apply communication science approaches to the investigation of behavioral targets and health outcomes related to cancer prevention and control. Applications should utilize one or more innovative communication research methodologies.

This Funding Opportunity Announcement (FOA) supports Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that will develop and/or validate devices or electronic systems that can: 1) monitor biologically- or behaviorally-based processes applicable to mind and body interventions or 2) be used to assist in optimizing the practice or increasing the efficacy of mind and body interventions.  The applications should: 1) lead to the development of new technologies, 2) adapt existing innovative technologies, devices and/or electronic systems, 3) repurpose existing devices and electronic systems, or 4) conduct testing of single or combined components of an integrated, long term, automated, wearable monitoring, stimulation device or electronic system in order to monitor or enhance the mechanistic processes or functional outcomes of mind and body interventions. For the purposes of this FOA, mind and body interventions are defined as non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), or combined mind and body meditative movement approaches (e.g., yoga, tai-chi, qigong).  

This funding opportunity announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) to develop and validate next-generation single cell analysis technologies and tools. The purpose is to foster the commercialization of innovative single cell analysis technologies for their broad use in biomedical research. The novel single-cell analysis technologies will aid in obtaining a fine-grained and dynamic view of heterogeneous cellular states and intercellular interactions, thereby providing new mechanistic insight into biological processes in health and disease. Applications should define the current state of technologies and tools as a benchmark against which the new approach(es) will be measured. The new approach(es) should provide substantially improved performance in sensitivity, selectivity, spatiotemporal resolution, scalability, multiplexing capability, or non-destructive analysis of molecular or functional measures of single cells.

This Funding Opportunity Announcement (FOA), encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required. In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. r NIEHS may support projects with a focus on innovative technology and method development. Also listed under R01

This notice solicits applications for the R40 Maternal and Child Health (MCH) Field-Initiated Innovative Research Studies (FIRST) Program. The purpose of the MCH FIRST Program grant is to advance the health and wellbeing of MCH populations by supporting innovative, applied, and translational intervention[1] research studies on critical issues affecting MCH populations. [1] For the purpose of this NOFO, an "intervention" is defined to include behavioral, social, or structural / health systems approaches, as well as combination applied clinico-medical and behavioral, social, or structural / health system approaches that contribute to the prevention of diseases or improvement of health (including clinical) outcomes for mothers, children and families at a population level.

Through this Call for Expressions of Interest (EOI), USAID/Mexico seeks partners to research, develop, test and evaluate innovative approaches to increase access to finance and catalyze investments to reduce deforestation and forest degradation in Mexico by improving land management practices and reducing the drivers of land-use change. þffBlended finance is the strategic use of development funds, such as those from government aid and philanthropic sources, to mobilize private capital for social and environment results, such as improving infrastructure, education, agriculture, healthcare, and more. Blended finance strategies are designed to encourage members of the private sector, such as companies and investors, to invest in activities and projects that can achieve both financial returns and positive social and environmental outcomes. Through this Addendum to the Broad Agency Announcement (BAA-MEX-PCM-2020), USAID/Mexico seeks partners to research, develop, test and evaluate innovative approaches to increase access to finance and catalyze investments to reduce deforestation and forest degradation in Mexico by improving land management practices and reducing the drivers of land-use change, especially in the States of Campeche, Chiapas, Jalisco, Oaxaca, and Quintana Roo.